November 6, 2017
Showcasing research from the group of Dr Maxim S. Pshenichnikov and Dr. Thomas Lacour Jansen at the Zernike Institute for Advanced Materials, University of Groningen, The Netherlands
June 14, 2017
Natural photosynthetic complexes have evolved to successfully operate under extreme low light conditions. Their tubular structure inspired the scientists to mimic nature with artificial nanotubes made of smart molecules, which are “programmed” to self-assemble in tubes without any human intervention. Changing the nanotubes sizes, which is of great interest for potential applications, requires re-programming the molecules.
May 19, 2017
Proteins, the engines of life, form the basis for all vital functions in all living systems. Most commonly, the biological functions of the proteins are imposed by their well-defined structures. This is not the case, however, for the so-called intrinsically disordered proteins (IDP), which e.g. are involved in DNA repair. In IDPs, the structural motifs are labile, rapidly fluctuating between conformations, which makes them very challenging to study.
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Within the project “Self-assembly pathways of an artificial light harvesting complex”, funded by the Dutch Research Council (NWO), two PhD positions are available at University of Groningen (the Netherlands). The aim of the project is to study how thousands and thousands of molecules organize themselves into highly-ordered functional structures without external guidance. The key to elucidating self-assembly intermediate stages and their kinetics is to confront the spectroscopic data with those predicted theoretical calculations. As such, the project implies strong collaboration between the two PhDs when the theoretical and experimental activities are cross-fertilized to reach the project goals. PhD students will be enrolled in the Groningen Graduate School of Science and Engineering .
The project aims at using a combination of microfluidics and advanced optical spectroscopy to obtain the two-dimensional (2D) spectra of self-assembled species. Microfluidics settings will project self-assembling kinetics onto the coordinate along the microfluidics channel. The optical properties of the intermediate species will be interrogated by 2D spectroscopy which – together with theoretical modelling – allows accurate retrieval of the structural information.
The PhD student will gain experience in designing of microfluidics cells and applying two-dimensional correlation spectroscopy to reveal different stages of molecular self-assembly. The position will be embedded within the Optical Condensed Matter Physics group of the Zernike Institute for Advanced Materials.
The main goals of this project are to unravel the spectral signatures of self-assembly intermediates by combining molecular dynamics simulations (MD), time-dependent density functional theory (TD-DFT) and advanced spectral simulation techniques. From MD structural intermediates will be predicted, the electronic states will be obtained through TD-DFT calculations, which serves as input for an efficient mapping procedure to predict the two-dimensional spectra of the intermediates. The predicted spectra – together with the experimental data – allow unraveling the self-assembly pathway.
The PhD student will gain experience in multiscale modelling approaches for predicting and interpretation of two-dimensional correlation spectroscopy of self-assembly processes. The position will be embedded within the Theory of Condensed Matter group of the Zernike Institute for Advanced Materials.
Information and application
Please provide an application/motivation letter, emphasizing your specific interest and motivation to apply for this position, a detailed CV, contact details of at least 2 referees, academic transcripts of B.Sc. and M.Sc. education, in a single pdf file. An (online) interview will be part of the selection procedure.
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The University of Groningen (UG) was founded in 1614, making it the oldest university in the Netherlands after Leiden. It is the 3rd largest university in the Netherlands, with over 33,500 students, 450 professors and 5000 employees. UG brought forward 2 Nobel Prize winners: Zernike (1953) and Feringa (2016). RUG is placed in the top 100 universities worldwide according to four international ranking tables.Within the UG, the Zernike Institute for Advanced Materials (ZIAM) has ranked 4th world wide in terms of citations and impact in Materials Science (Thomson Reuters, 6/2011) and 9th in the THE ranking in Materials Science (1999-2009). Its approximately 250 physicists, chemists, and biologists work together on fundamental leading-edge research in materials science. In the national evaluation in 2010 the Zernike Institute was ranked "exemplary".
Groningen is a vibrant, one thousand year old city in the North of The Netherlands. It combines a rich academic tradition with an attractive city life, characterized by culture, history, and an exciting social scene. Groningen is tailored around students who comprise around one-third of the city's residents. Groningen is popularly referred to as "The World Cycling City" because of integrated, labelled bike paths all around the city.